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KMID : 0861020090240030079
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Korea Journal of Herbology
2009 Volume.24 No. 3 p.79 ~ p.86
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Anti-inflammatory Effect of Coptidis Rhizoma
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Yoon Kwang-Ro
Kim Yong-Jin
Lee Eun
Lee Joon-Moo
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Abstract
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Objectives : The present study investigated Inflammatory effect of Coptidis Rhizoma in lipopolysaccharideexposed rats and Raw 264.7 cells.
Methods： The plasma concentration of IL-1, IL-6 and TNF- peaked at 5 h after LPS injection, and the values of the Coptidis Rhizoma extract groups were lower than those of the control group. In the increment of cytokines concentration at 2 h and 5 h after LPS injection, the Coptidis Rhizoma groups were lower than that of control group. The plasma concentration of IL-10 peaked at 5 h after LPS injection, and the values of the Coptidis Rhizoma extract groups were higher than those of the control group. In the increment of cytokines concentration at 2 h and 5 h after LPS injection, the Coptidis Rhizoma groups were higher than that of control group. Liver cytokines measurement was done at 5 h after LPS injection. The concentration of liver IL-1 and IL-6 in the Coptidis Rhizoma groups was lower than that of the control group. The concentrations of liver TNF-, and IL-10 showed no significant differences among all the treatment groups.
Results： In the studies of lipopolysaccharide-exposed Raw 264.7 cells, the concentration of IL-1, IL-6 and TNF- in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group), and in the lipopolysaccharide-exposed cells groups, these values showed a tendency to decrease in the Coptidis Rhizoma groups. The concentration of IL-10 in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group), and in the lipopolysaccharide-exposed cells groups, the values showed a tendency to increase in the Coptidis Rhizoma groups.
Conclusions： These results indicate that the Coptidis Rhizoma extracts have an functional material for Inflammatory activities.
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KEYWORD
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Anti-inflammatory effect, Coptidis Rhizoma, LPS shock, cytokines, Raw 264.7 cells
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